AMPK/mTOR pathway and leucine resistance in sepsis
- VernacularTitle:AMPK／mTOR 通路参与脓毒症亮氨酸抵抗的研究进展
- Author:
Wenfei LIU
;
Zhenxin ZHU
;
Ronglin YAN
- Publication Type:Journal Article
- Keywords:
AMPK;
mTOR;
Sepsis;
Leucine resistance
- From:
Journal of Medical Postgraduates
2014;(12):1311-1314
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis leads to inhibition of protein synthesis , known as leucine resistance .mTOR regulates protein synthesis by phosphorylation of S6K1 and 4E-BP1.AMPK is an important negative regulator of mTOR and its activity is in an abnormal state in sep-sis.This review briefly discusses the AMPK/mTOR pathway in Sepsis-induced leucine resistance .
