Molecular targeting therapy for gastric cancer
- VernacularTitle:胃癌分子靶向治疗的研究进展
- Author:
Nandie WU
;
Jia WEI
;
Baorui LIU
- Publication Type:Journal Article
- Keywords:
Gastric cancer;
Molecular therapy;
Driver genes
- From:
Journal of Medical Postgraduates
2014;(12):1318-1322
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer is the fifth most common cancer and the third leading cause of death globally .Apart from the suc-cessful phase Ⅲclinical trial of trastuzumab and Ramucirumab , other targeted therapies in gastric cancer ( GC) have fallen short or still in early clinical development .In this review, we will summarize the most up to date information on many of the potential actionabledriver genesin gastric cancer and the importance of using the optimal diagnostic test to select for these molecularly defined patients . We focus on the following aspects:HER-2, EGFR, FGFR, MET, IGF-1R and VEGF.
