Expression of TSLC1 in human gastric cancer and its clinical significance
10.13315/j.cnki.cjcep.2014.12.003
- VernacularTitle:胃癌组织中TSLC1的表达及临床意义
- Author:
Shuai YANG
;
Hua HU
;
Xiaoyu WANG
;
Qiang ZHAO
;
Xiaoli ZHANG
- Publication Type:Journal Article
- Keywords:
gastric neoplasms;
tumor suppressor in lung cancer 1;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2014;(12):1339-1341
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the relationship between tumor suppressor in lung cancer 1 (TSLC1) protein expression and the carci-nogenesis and progression of human gastric carcinoma. Methods Expression of TSLC1 protein in 20 normal gastric mucosa, 30 intra-epithelial neoplasias ( IN) and 50 gastric cancers was examined by immunohistochemistry. Results The expression of TSLC1 in gas-tric cancer was 14. 00% which was lower than that in IN (46. 67%) and normal gastric mucosa (95. 00%, P<0. 05). TSLC1 ex-pression in high-grade IN was lower than that in low-grade IN and normal gastric mucosa (P<0. 05). TSLC1 expression in high-grade IN and gastric cancer was of no significant difference ( P>0. 05 ) . Expression of TSLC1 was significantly associated with lymph node metastasis and TNM in gastric cancer (P<0. 05). Conclusion The expression of TSLC1 is closely related to carcinogenesis, lymph node metastasis and clinical stage in gastric cancer, which suggest that TSLC1 may be a new target for the prevention and treatment of gastric cancer.
