Expression of Par3, Par6 and aPKC in gastric carcinoma and their significance
10.13315/j.cnki.cjcep.2014.12.004
- VernacularTitle:Par3、Par6及aPKC蛋白在胃癌发生、发展中的意义
- Author:
Zhongtang XIONG
;
Sheng ZHANG
;
Xingfu WANG
;
Ke ZHENG
;
Hong CHEN
;
Yupeng CHEN
- Publication Type:Journal Article
- Keywords:
gastric neoplasms;
Par3;
Par6;
aPKC;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2014;(12):1342-1345
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of Par3, Par6 and aPKC in gastric carcinoma and their significance. Method Ex-pression of Par3, Par6 and aPKC, by using immunohistochemistry, was detected in different sites of gastric carcinoma ( including the gastric carcinoma in gastric mucosa, the central area and the invasive front of gastric carcinoma) and the lymph node metastasis, using normal gastric mucosa as controls. Results Expression of Par3, Par6 and aPKC in different sites of gastric carcinoma was lower than in that of normal gastric mucosa (P<0. 01). Expression of Par3, Par6 and aPKC was obviously lower in gastric carcinoma with gastric phenotype than in that with intestinal phenotype and mixed phenotype of gastric carcinoma (P<0. 05, P<0. 01, P<0. 01);the rate of down-regulation of Par6 and aPKC in gastric carcinoma with invasion to ectoptygma and out of ectoptygma was obviously higher than that in gastric carcinoma which located at mucosa and under mucosa (P both<0. 01), and the rate of down-regulation of Par6 in gas-tric carcinoma with lymph node metastasis was obviously lower than that with no lymph node metastasis ( P>0. 05 ) . Conclusions The down-regulation expression of Par3, Par6 and aPKC may promote the carcinogenesis and progression of gastric carcinoma.
