Expression of spliced XBP-1 s and ADRP in kidney of diabetic rats
10.13315/j.cnki.cjcep.2014.12.011
- VernacularTitle:糖尿病大鼠肾脏组织中XBP-1 s和ADRP的表达
- Author:
Lin ZHU
;
Jun HAO
;
Song ZHAO
;
Xue ZHAO
;
Ning CHEN
;
Shushen ZHENG
;
Huijun DUAN
- Publication Type:Journal Article
- Keywords:
diabetes mellitus;
renal tubular cells;
rat;
spliced X-box binding protein-1;
adipose differentiation related protein
- From:
Chinese Journal of Clinical and Experimental Pathology
2014;(12):1371-1374
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of XBP-1s and ADRP in kidney of diabetic rats. Methods Diabetic rat models were successfully established by intraperitoneal injection of STZ. After two months rats were sacrificed and XBP-1s and ADRP were de-tected by immunohistochemistry and Western blot. Results XBP-1s and ADRP were located in renal tubular cells and increased by a-bout 2. 017 times and 1. 544 times in comparison with normal control rats (P<0. 05). Moreover, it was shown that high expression of XBP-1s was commonly accompanied with increased ADRP by Pearson correlation analysis and the correlation coefficient was 0. 723 (P<0. 05). Conclusion The increased XBP-1s may cause the up-regulation of ADRP in the kidney of diabetic rats.
