A clinical study on the prevention of obstruction of biliary stent with ursodeoxycholic acid Huang
10.3760/cma.j.issn.1007-5232.2014.11.003
- VernacularTitle:熊去氧胆酸预防胆道塑料支架再阻塞的临床研究
- Author:
Wen LYU
;
Xia WANG
;
Hangbing JIN
;
Jie FANG
;
Xiaofeng ZHANG
;
Xiao ZHANG
- Publication Type:Journal Article
- Keywords:
Stents;
Obstruction;
Bilirubin;
Ursodeoxycholic acid;
Antiperinuclear factor
- From:
Chinese Journal of Digestive Endoscopy
2014;(11):628-630
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate efficacy and safety of ursodeoxycholic acid(UDCA)for preven-tion of obstruction of biliary plastic stent.Methods A total of 88 patients with plastic biliary stents at our hospital were divided into UDCA group and the control group.Stents were collected 3 months after the opera-tion for argile biliare in the stent.The contents of APF,calcium bilirubin and calcium carbonate were ana-lyzed by biochemistry,and bacterium culture was conducted.Results The obstruction rate of UDCA group (n=43)and control group(n=45)were 8. 9% and 58. 1% respectively with significant differences(P<0. 05).There were significant differences in the protein level of APF between the UDCA group(17. 29 ± 9. 52)μm/L and the control group(10. 39 ±2. 17)μm/L(P<0. 05).Calcium bilirubin[(13. 90 ±3. 80) vs.(30. 92 ±7. 07)]and calcium carbonate[(12. 60 ±5. 69)vs.(16. 52 ±4. 11)]were less than those of the control group (P<0. 05 ).Only one type of bacterium was found,and Escherichia coli were cultured in 40. 0% samples,a lower incidence compared with the control(72. 1%).Conclusion UDCA would lessen biofilm and smooth stent surface by promoting secretion of endogenous bile acid and increasing APF,and keep the biliary patency.
