The curative effect of ursodeoxycholi acid on retinopathy of prematurity in newborn rats
10.3969/j.issn.1000-3606.2014.12.018
- VernacularTitle:熊去氧胆酸治疗新生大鼠视网膜损害初探
- Author:
Guoqing ZHANG
;
Jing LI
;
Jun BU
;
Jianhua SUN
;
Ping HUANG
- Publication Type:Journal Article
- Keywords:
retinopathy;
ursodeoxycholi acid;
preterm
- From:
Journal of Clinical Pediatrics
2014;(12):1168-1170
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the curative effect of ursodeoxycholi acid on retinopathy of prematurity (ROP) caused by high concentration of oxygen in newborn rats. Methods The model of ROP was established. Neonatal rats were divided into normal control group, ROP model group, low dose ursodeoxycholi acid treatment group (10mg/kg) and high dose ursodeoxycholi acid treatment group (40mg/kg). Rats were sacrificed at days 17. The new retinal vessels were observed and counted under lfuorescence microscope. Results The new retinal vessels in ROP rats were hyperplastic, twisted and unevenly distributed. There was signiifcant difference in the number of new retinal vessels among different groups (P=0.000). The number of new retinal vessels of rats in ROP group, low-dose group and high-dose group was signiifcantly more than that in control group (P=0.000). The number of new retinal vessels in low-dose group and high-dose group was significantly less than that in ROP group (P<0.05). The number of new retinal vessels in high-dose group was less than that in low-dose group (P>0.05). Conclusions Ursodeoxycholi acid could inhibit the angiogenesis of retina and could have curative effect on ROP.
