Advances in research of the relationship between adhesion molecules and pathogenesis of Kawasaki disease
10.3969/j.issn.1000-3606.2014.12.023
- VernacularTitle:黏附分子与川崎病发病机制关系的研究进展
- Author:
Lumen CHAO
;
Baiyu CHEN
- Publication Type:Journal Article
- Keywords:
adhesion molecules;
Kawasaki disease;
pathogenesis
- From:
Journal of Clinical Pediatrics
2014;(12):1194-1197
- CountryChina
- Language:Chinese
-
Abstract:
Adhesion molecules (AM) are a class of molecules that can mediate cell-to-cell and cell-to-matrix interaction. They participate in the cellular recognition, signal transduction, cell proliferation and differentiation, cell stretching and movement through ligand-to-receptor interaction. AM are the molecular basis of immune response, inflammation, blood coagulation, tumor metastasis, wound healing and a series of physiological and pathological processes. Kawasaki disease (KD) is an acute systemic small vasculitis syndrome, mainly affecting coronary artery. KD is the main cause for acquired heart disease in children. To study the relationship between AM and pathogenesis of KD is important in the understanding of KD pathogenesis, prevention and treatment of coronary artery lesions complicated with KD. This review focused on the relationship between AM and pathogenesis of KD.
