X-ray evaluation of alpha-calcium sulfate hemiydrate/biphasic bioceramics bone for repairing bone defects of rabbit radius
10.3969/j.issn.2095-4344.2014.47.002
- VernacularTitle:新型α-半水硫酸钙/双相生物陶瓷人工骨修复兔桡骨骨缺损的X射线评估
- Author:
Biao YAO
;
Weiqing QIAN
;
Hong YIN
- Publication Type:Journal Article
- Keywords:
calcium sulfate;
ceramics;
X-rays
- From:
Chinese Journal of Tissue Engineering Research
2014;(47):7550-7555
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Alpha-calcium sulfate hemiydrate/biphasic bioceramics (α-CSH/BCP) as a bone repair material has been widely used in the clinic, but there are stil some deficiencies. OBJECTIVE:To observe the effect of α-CSH/BCP on the repair of bone defects of the radius in rabbits. METHODS:The unilateral radius of 18 adult New Zealand white rabbits was selected to establish bone defect models, and then these rabbit models were randomized into three groups that were treated with α-CSH,α-CSH/BCP, BCP materials, respectively. At 4, 8, 12 weeks after implantation, bone samples were taken for gross and X-ray observations. RESULTS AND CONCLUSION: (1) Gross observation: At 12 weeks of implantation, the bone defect was completely repaired in the α-CSH/BCP group, and the defected radius recovered basicaly; in the α-CSH group, bone defects were visible; and in the BCP group, there was stil some material for filing and coverage. (2) X-ray observation: In the α-CSH group, the degradation of implanted materials was faster than new bone formation, and bone defects were visible; in the α-CSH/BCP group, bone defects were healed, cortical bone remodeling was good, and the bone marrow cavity was re-canalized; in the BCP group, the implanted materials were stil visible, and bone defects were not repaired. These findings indicate that the α-CSH/BCP bone repair material can significantly promote the repair of bone defects of rabbit radius, with a better repair effect than α-CSH or BCP alone.
