Hyaluronic acid for the treatment of chronic periodontitis can effectively promote periodontal tissue regeneration
10.3969/j.issn.2095-4344.2014.47.019
- VernacularTitle:医用透明质酸修复慢性牙周炎：可有效促进牙周组织再生
- Author:
Xi YAO
;
Yunsheng LI
;
Hongmei LI
;
Yongyu DAI
- Publication Type:Journal Article
- Keywords:
hyaluronic acid;
chronic periodontitis;
dental plaque index
- From:
Chinese Journal of Tissue Engineering Research
2014;(47):7648-7652
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Hyaluronic acid has antioxidant, immune regulation, anti-inflammatory roles as wel as promotes wound healing. Hyaluronic acid is more and more applied in the treatment of chronic periodontitis and achieves a significant effect. OBJECTIVE: To observe the clinical effects of local application of sodium hyaluronate in the treatment of chronic periodontitis. METHODS:Sixty cases of chronic periodontitis (300 teeth) were selected. According to self-control method, the teeth in district A, 150 premolars or molars, were as experimental group, and other 150 teeth in district B served as control group. In the experimental group, periodontal scaling, subgingival scaling, and local application of Gengigel gel (0.2% hyaluronic acid) in the gingival sulcus were employed; in the control group, the treatment was same to that in the experimental group except local application of Gengigel gel. During 8-week folow-up, dental plaque index, sulcus bleeding index, probing depth, and clinical attachment loss were changed dynamicaly. RESULTS AND CONCLUSION:After treatment, al the measurement indexes were improved remarkably in the two groups. However, there was no difference in the dental plaque index between the two groups at 1, 4, 8 weeks after treatment. The sulcus bleeding index was lower in the experimental group than the control group at 1, 4, 8 weeks after treatment (P < 0.05). The periodontal probing depth of the experimental group was lower than that of the control group at 4 and 8 weeks (P < 0.05). The clinical attachment loss was lower in the experimental group than the control group at 8 weeks (P < 0.05). These findings indicate that periodontal treatment with local application of sodium hyaluronate in the gingival sulcus is significantly effective for the treatment of chronic periodontitis.
