Correlation studies of VEGF-C/D and its receptor with lymph node metastasis in gastric cancer
10.3969/j.issn.1000-8179.20140407
- VernacularTitle:VEGF-C/D及其受体与胃癌淋巴转移关系的研究进展
- Author:
Yachao HOU
;
Jingyu DENG
;
Han LIANG
- Publication Type:Journal Article
- Keywords:
vascular endothelial growth factor-C/D;
vascular endothelial growth factor receptor-3;
gastric cancer;
lymph node me-tastasis
- From:
Chinese Journal of Clinical Oncology
2014;(24):1608-1611
- CountryChina
- Language:Chinese
-
Abstract:
The lymphatic vessel is a crucial pathway for tumor metastasis. The discovery of more lymphatic growth factors and lymphatic vessel markers signifies the significant progress of studies on the role of vascular endothelial growth factor-C/D (VEGF-C/D) and one of its specific receptors in the mechanisms of tumor lymph-angiogenesis and lymph node metastasis. VEGF-C/D expression is related to the clinicopathologic features of gastric cancer, including lymph metastasis, micro-lymphatic vessel density in the paraneo-plastic tissues, survival rate, and prognosis. Experimental animal models and in vitro experiments show that suppression of VEGF-C/D expression is beneficial in gastric cancer treatment. This article provides an overview of the association between VEGF-C/D and lymph node metastasis in gastric cancer.
