Higher Plasma Thrombospondin-1 Levels in Patients With Coronary Artery Disease and Diabetes Mellitus.
10.4070/kcj.2012.42.2.100
- Author:
Kyu Young CHOI
1
;
Dong Bin KIM
;
Myung Jun KIM
;
Bum June KWON
;
Seo Yoon CHANG
;
Sung Won JANG
;
Eun Joo CHO
;
Tai Ho RHO
;
Jae Hyung KIM
Author Information
1. Departemnt of Cardiology, The Catholic University of Korea College of Medicine, Seoul, Korea. dbkimmd@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Thrombospondin-1;
Coronary artery disease;
Diabetes mellitus
- MeSH:
Aluminum Hydroxide;
Animals;
Atherosclerosis;
Carbonates;
Coronary Angiography;
Coronary Artery Disease;
Coronary Vessels;
Diabetes Mellitus;
Hemoglobins;
Humans;
Male;
Multivariate Analysis;
Plasma;
Thrombospondin 1
- From:Korean Circulation Journal
2012;42(2):100-106
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Thrombospondin-1 (TSP-1) is associated with atherosclerosis in animals with diabetes mellitus (DM). But, no study has investigated the role of TSP-1 in human atherosclerosis. This study investigated the relationship among plasma TSP-1 concentration, DM, and coronary artery disease (CAD). SUBJECTS AND METHODS: The study involved 374 consecutive subjects with suspected CAD, who had undergone coronary angiography to evaluate effort angina. Patients were divided into four groups as follows: DM(-) and CAD(-), DM(-) and CAD(+), DM(+) and CAD(-), and DM (+) and CAD(+). RESULTS: We found that plasma TSP-1 levels were higher in patients with DM(+) and CAD(+) (n=103) than those in other patients (n=271) (p<0.01). A multivariate analysis showed that male gender {odds ratio (OR), 2.728; 95% confidence interval (CI), 1.035-7.187}, high density lipoprotein-cholesterol (OR, 0.925; 95% CI, 0.874-0.980), glycated hemoglobin (OR, 1.373; 95% CI, 1.037-1.817), and plasma TSP-1 (OR, 1.004; 95% CI, 1.000-1.008) levels were independently associated with the presence of CAD in patients with DM. CONCLUSION: Plasma TSP-1 levels were higher in patients with DM(+) and CAD(+) than those in other patients, and plasma TSP-1 levels were independently associated with the presence of CAD in patients with DM. These findings show a possible link between human plasma TSP-1 concentration and CAD in patients with DM.
