Transmission of mouse senile amyloid fibrils in skeletal muscle
10.3969/cjz.j.issn.1002-2694.2014.12.006
- VernacularTitle:探讨小鼠肌肉组织中老化淀粉样变纤维的传播性
- Author:
Jia HUO
;
Junqiao QIAN
;
Chenli LI
;
Keiichi HIGUCHI
;
Qianyu GUO
;
Jinze QIAN
- Publication Type:Journal Article
- Keywords:
mouse senile amyloid fibrils;
skeletal muscle;
secondary transmission
- From:
Chinese Journal of Zoonoses
2014;(12):1201-1205
- CountryChina
- Language:Chinese
-
Abstract:
ABSTRACT:Recently ,prion‐like transmission has been found in various amyloidosis .AApoAII amyloid fibrils in mouse senile amyloidosis have exhibited transmissibility .AApoAII amyloid fibrils ,which were excreted from mice and contained in fe‐ces or milk ,cause mouse senile amyloidosis .However ,transmissibility of AApoAII amyloid fibrils through other pathways has not yet been established .In this study ,we injected AApoAII amyloid fibrils into R1 .P1‐A poa2c mice to induce AApoAII sys‐temic amyloidosis .Two months later ,AApoAII amyloid fibrils ,which deposited in the skeletal muscles of amyloid‐affected mice ,were used to induce AApoAII systemic amyloidosis .Mouse senile amyloidosis which deposited in skeletal muscles could induce secondary transmission of AApoAII amyloidosis .The evidence of transmission through skeletal muscles in non‐prion systemic amyloidosis is found in our study .This pathway of transmission provides new insight into the potential for food‐borne pathogenesis and etiology of systemic amyloidosis .
