Serum total bili rubin,prothrombin,HBeAg,and PC mutant--predictors of severe acute exacerbation in patients with chronic hepatitis B

VernacularTitle:严重乙型肝炎活动进展为肝衰竭的预后因素分析
Author: Ling YANG ; Qian JIAO ; Wenting ZENG ; Zengwei LIANG ; Xueshuo XIE
Publication Type:Journal Article
Keywords: hepatitis B virus; liver failure; viral mutant
From: Chinese Journal of Zoonoses 2014;(12):1218-1222
CountryChina
Language:Chinese
Abstract: ABSTRACT:In this study ,we elucidated the predictors of progression to liver failure during severe acute exacerbation .We analyzed 69 consecutive patients with severe acute exacerbation of chronic hepatitis B for clinical outcome and factors that influ‐enced the development of liver failure ,including viral genotype ,PC (G1896A) and BCP (A1762T/G1764A) mutants .Thirty‐three (47 .8% ) severe acute exacerbation patients progressed to liver failure .Multivariate analysis identified serum bilirubin (TB>256 μmol/dL ,P=0 .008) and prothrombin activity (PTA<40% ,P<0 .001) as significant determinants of progression to liver failure .HBeAg negativity (P=0 .065) and PC mutant (P=0 .090) were associated with the progression to hepatic de‐compensation .Serum total bilirubin ,prothrombin activities ,HBeAg status and PC mutant were predictors of clinical outcome in patients with severe acute exacerbation of chronic hepatitis B .