To observe the NTBC dependence of Fah-knockout mice
10.3969/j.issn.1671.7856.2014.011.001
- VernacularTitle:Fah －／－小鼠对 NTBC 的药物依赖性观察
- Author:
Yuting PENG
;
Xin WU
;
Xiangping KONG
;
Shaolin LI
;
Guangze LIU
- Publication Type:Journal Article
- Keywords:
Fah-knockout mice;
NTBC;
Liver failure;
Tyrosinemia type I
- From:
Chinese Journal of Comparative Medicine
2014;(11):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the NTBC dependence of Fah-knockout mice and study the biological characteristics in order to use the model more effectively.Methods Examine the progressive changes in body weight, survival time, liver pathology and serological markers after the NTBC withdrawal.Results After removing of NTBC, Fah-knockout mice lost their body weight gradually, and finally died in 5 to 7 weeks, along with increased serum ALT, AST levels and deformation of the hepatocytes.Conclusions Fah-knockout mice have a strong drug dependence of NTBC and could be the ideal model to hereditary tyrosinemia type I and other liver injury.
