Influence of atrial fibrillation on NT-proBNP for diagnosing acute heart failure
10.3969/j.issn.1671-8348.2014.36.021
- VernacularTitle:心房颤动对 NT-proBNP 诊断急性心力衰竭的影响
- Author:
Qin DUAN
;
Dongying ZHANG
- Publication Type:Journal Article
- Keywords:
N-terminal pro-brain natriuretic peptide;
atrial fibrillation;
acute heart failure;
ROC curve
- From:
Chongqing Medicine
2014;(36):4917-4919
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the influence of atrial fibrillation(AF) on N‐terminal pro‐brain natriuretic peptide(NT‐proB‐NP) for the assist diagnosis of acute heart failure(AHF) .Methods Totally 457 inpatients with suspected AHF due to acute dysp‐nea and conducting blood NT‐proBNP detection and electrocardiogram(ECG) within 24 h of admission were collected and devided into groups according to whether AHF was diagnosed and complicated with AF identified by ECG on admission ,that was AHF +AF group ,AHF + non AF group ,non AHF + AF group ,non AHF + non AF group .The receiver operating characteristic (ROC) curve was adopted to evaluate the value of NT‐proBNP for diagnosing AHF .Results Among 457 cases ,194 cases (42 .5% ) were diagnosed as AHF and 140 cases (42 .5% ) as AF .The NT‐proBNP level in the AF group was significantly higher than that in the non AF group (4 482 .0 pg/mL vs .1 302 .0 pg/mL ,P < 0 .01) .The NT‐proBNP level had no statistical difference between the AHF + AF group and the AHF + non AF group AF(6 580 .0 pg/mL vs .6 769 .0 pg/mL ,P> 0 .05) .The NT‐proBNP level in the non AHF + AF group was significantly increased compared with the non AHF + non AF group (403 .3 pg/mL vs .2 892 .0 pg/mL ,P< 0 .01) .The area under the curve(AUC) of NT‐proBNP for diagnosing AHF in the AF group and the non AF group was 0 .759(95% CI :0 .677 - 0 .841 ,P < 0 .01) and 0 .931(95% CI :0 .903 - 0 .985 ,P < 0 .01) .Conclusion The NT‐proBNP level in AF patients without AHF is significantly increased ,which might affect the value of NT‐proBNP in the diagnosis of AHF .In the clinical applica‐tion ,whether the patient has AF cardiac rhythm should be paid attention to for better interpretating the detection result of NT‐proBNP .
