Experiment study on the repairing effect of hyalurnic acid hydrogel on rat articular cattilage defects
10.3969/j.issn.1671-8348.2014.35.005
- VernacularTitle:透明质酸水凝胶修复大鼠软骨缺损的实验研究
- Author:
Hui WANG
- Publication Type:Journal Article
- Keywords:
hyaluronic acid;
biocompatible materials;
articular cartilage;
reconstructive surgical procedures
- From:
Chongqing Medicine
2014;(35):4719-4722
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the repairing effect of hyaluronic acid hydrogel on rat articular cartilage defects .Methods One hundred and twenty SD rats were randomly divided into group A (natural repair group) ,group B (hyaluronic acid group) and group C (composite material group) ,36 rats was in each group and 12 rats were used to obtain cartilage cells .Full‐thickness articular os‐teochondral defects(2 .5 mm in diameter and 3 .0 mm in depth)were created mechanically in femoral trochlea of rats .Histological and biochemical method were used to evaluate the repairing effect of different material at different points(10 ,20 ,40 d) .Results Repairing effect of group C was best by histological and biochemical method at different points ,followed by group B ,and they were better than that of group A .Conclusion Hyaluronic acid hydrogel could provide cartilage cell proliferation for porous space truss structure ,and could carry cartilage cells at the same time .the cellular space truss structure have high surrounding tissue compatibil‐ity and biodegradation ,it is helpful for cartilage cell survival ,reproduction and division .
