The clinical efficacy of Citric acid tandospirone in treating generalized anxiety neurosis
10.3760/cma.j.issn.1008-6706.2014.24.015
- VernacularTitle:枸橼酸坦度螺酮治疗首发广泛性焦虑疗效观察
- Author:
Guomin WANG
;
Xiaofeng GAO
;
Bo ZHOU
- Publication Type:Journal Article
- Keywords:
Tandospirone;
Generalized anxiety disorder;
Adverse reactions
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(24):3717-3718
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate clinical efficacy and adverse reactions of Citric acid tandospirone in treating generalized anxiety neurosis.By doing this study,we provide clinical evidence for citric acid tandospirone in treating generalized anxiety neurosis.Methods 92 patients with generalized anxiety were randomly divided into the control group and observation group according to the random number table.There were 46 cases in each group.In the observation group,the patients were given acid citrate edge tandospirone.At the starting the patients were taken 15mg/d. After 3 days the dose increased to 35mg/d by 5mg.The average dose was (31 ±3.4)mg/d.In control group,accord-ing to different patients sleep condition,oxazepam tablets were taken.The daily dosage does not exceed 30mg/d.After two weeks,the dose was gradually reduced to the end.The clinical efficacy,HAMA score and adverse reactions in the two groups were compared.Results Compared to prior treatment,after 2 weeks and 4 weeks the HAMA score in the two groups were significantly different (P<0.05).Compared with the control group,the score in the two group had significantly different after two weeks treatment (t=2.16,P<0.05).The total effective in the observation group was 86.9 %.In the control group the total effective rate was 82.6%.There was no significant difference between the two groups (χ2 =0.33,P>0.05).The rate of adverse reaction in the observation group was 32.6%.The rate of adverse reaction in the control group was 63%.The rate of adverse reaction in the control group and observation group had sig-nificantly different (χ2 =8.58,P<0.05) .Conclusion Acid citrate edge tandospirone on the treatment of general-ized anxiety neurosis showed obviously effect and had fewer adverse reactions.The clinical program is worth of further study and clinical application.
