The clinical effects of cowpox vaccination in inflammatory skin extract in the treatment ofdiabetic peripheral neuropathy
10.3760/cma.j.issn.1008-6706.2014.24.025
- VernacularTitle:牛痘疫苗致炎兔皮提取物治疗糖尿病周围神经病变的临床探讨
- Author:
Zhiguang LIU
- Publication Type:Journal Article
- Keywords:
Diabetic neuropathies;
Viral vaccines;
Tissue extracts;
Cysteine;
Insulin-like growth factor 1
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(24):3741-3743
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effectiveness of vaccinia vaccination rabbit inflammatory skin extracts on blood homocysteine(Hcy) and insulin-like growth factor-1(IGF-1) in patients with diabetic peripheral neuropathy. Methods 100 patients with diabetic peripheral neuropathy were randomly divided into the two groups,the observa-tion group(n=50 cases) and the control group(n=50 cases).The observation group was treated through vaccinia vaccination rabbit inflammatory skin extracts, while the control group was treated through mecobalamin.They were treated for 15 days.Median nerve,peroneal motor nerve conduction velocity (MCV) and sensory nerve conduction velocity ( SCV) were determined before and after treatment.Blood IGF-1 and Hcy were detected.Results TSS were significantly lowered after treatment (t=9.772,13.624,all P<0.01).Compared with the control group,the observa-tion group was significantly decreased (t=3.925,P<0.05).After treatment,the median nerve,peroneal nerve MCV and SCV were significantly increased (t=5.103,3.019,4.998,2.928,5.128,3.112,5.286,3.118,all P<0.05). Compared with the control group,theobservation group was observed to increase more significantly(t=2.826,2.743, 3.268,3.096,all P<0.05).After treatment,serum IGF-1 were significantly elevated,and compared with the control group after treatment,post-treatment observation group increased more significantly(t=4.179,P<0.05).After treat-ment plasma Hcy were significantly lower than that of the control group after treatment,the observation group after treatment significantly decreased(t=3.165,P<0.05).Conclusion Vaccinia vaccination rabbit inflammatory skin extracts can improve blood Hcy and IGF-1 in patients with diabetic peripheral neuropathy.
