Curative effect of IMRT dose cisplatin combined weeks clinical efficacy of treatment of elderly esophageal cancer
10.3760/cma.j.issn.1008-6706.2014.24.027
- VernacularTitle:调强放疗联合周剂量顺铂治疗老年人食管癌临床疗效观察
- Author:
Qingwen ZHAO
;
Jianfeng DIAO
;
Li SONG
;
Yun REN
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Intensity modulated radiation therapy;
Radiochemotherapy;
Aged
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(24):3746-3748
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the near future curative effect and toxicity of the combination of weekly dose of cisplatin in the treatment of elderly patients with esophageal cancer intensity-modulated radiotherapy observa-tion.Methods 60 patients with locally advanced esophageal cancer patients aged by method randomly were divided into synchronous chemotherapy group( CRT group) and 30 cases of radiotherapy alone group( RT group) 30 cases,the two groups using 6MV-X ray intensity modulated radiotherapy,radiotherapy dose:DT 60 Gy/30/6 week.The CRT treated group was given cisplatin 20-25mg/m2 in the radiotherapy of second day,1 times per week,a total of 6 times. Results Radiotherapy and chemotherapy, radiotherapy group recent effective rate were 80.0% and 63.3%, the difference was statistically significant(χ2 =5.934,P<0.05),P< 0.05).The main toxicity was myelosuppres-sion,radiation esophagitis,basically I and II,no statistically significant difference between the two groups(P>0.05). Conclusion Intensity modulated radiotherapy combined with weekly dose of cisplatin in the treatment of elderly patients with esophageal cancer significant short-term effect,less adverse reactions,patient tolerance is good,which is worth the clinical promotion.
