Clinical efficacy of the preventing antibiotic-associated diarrhea in infant with pneumonia using the live Clos-tridium butyricum and Bifidobacterium combined Powders
10.3760/cma.j.issn.1008-6706.2014.24.014
- VernacularTitle:酪酸梭菌二联活菌散预防肺炎婴幼儿抗生素相关性腹泻的临床观察
- Author:
Zheng YUAN
;
Wei CHEN
- Publication Type:Journal Article
- Keywords:
Clostridium;
Diarrhea;
Anti-bacterial agents;
Pneumonia;
Child
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(24):3715-3716
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe and evaluate the efficacy of the preventing antibiotic-associated diarrhea in infant with bacterial pneumonia using the live Clostridium butyricum and Bifidobacterium combined Powders. Methods 103 infants with bacterial pneumonia were randomly divided into the two groups,53 infants as the trial group,another 50 infants as the control group with normal antibacterial therapy,two or three hours afterword the live Clostridium butyricum and Bifidobacterium combined Powders was administered at dose of 0.5g ti-daily in the trial group,After diarrhea taken place,the live Clostridium butyricum and Bifidobacterium combined Powders was adminis-tered at dose of 0.5g ti-daily in the control group,to contrast the rate of secondary diarrhea and clinical efficacy in the two groups.Results The incidence of antibiotic-associated diarrhea was 13.2%( 7/53 ) in the trial group and 56.0%(28/50) in the control group (χ2 =21.00,P<0.01).There were significant differences between the two groups.Duration of diarrhea and period of treatment in the trial group was obviously shorter than that of the control group,the rate of dehydration in the trial group was lighter than that in the control group(χ2 =6.64,P<0.01). Conclusion The live Clostridium butyricum and Bifidobacterium combined powders with antibacterial therapy at reg-ular intervals can prevent antibiotic-associated diarrhea.It is worthy of preventive application.
