Application value of plasma Dˉdimer and coagulation indicators in patients with ovarian cancer
10.3969/j.issn.1673-4130.2014.24.004
- VernacularTitle:血浆D-二聚体及凝血指标在卵巢癌患者中的应用价值
- Author:
Hui GONG
;
Lingjuan GAO
;
Yajuan SU
- Publication Type:Journal Article
- Keywords:
ovarian cancer;
coagulation function;
D-dimer
- From:
International Journal of Laboratory Medicine
2014;(24):3307-3308
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of plasma D-dimer and coagulation indicators in the patients with o-varian cancer by detecting the routine coagulation indicators and plasma D-dimer level.Methods The plasma D-dimer and coagula-tion indicators levels were measured in 84 patients with ovarian cancer and 25 patients with benign ovarian tumor.The application value of preoperative plasma D-dimer level in monitoring the disease course of ovarian cancer was evaluated.Results The plasma levels of D-dimer and FBG in the ovarian cancer group were significantly higher than those in the ovarian benign tumor control group(P <0.01);moreover the plasma levels of D-dimer and FBG in the patients with the stage Ⅲ~Ⅳ ovarian cancer were signifi-cantly higher than those in the patients with the stageⅠ~Ⅱ ovarian cancer,the differences had statistical significance(P <0.05), which prompting that the coagulation and fibrinolysis dysfunction in the patients with ovarian cancer exhibited the aggravating trend with the disease condition progression.Conclusion D-dimer may reflect the excessive activation of fibrinolysis function in ovarian tumor,which prompting the survival period and prognosis in the patients with advanced ovarian cancer.The plasma D-dimer level has the important significance to early prevention,early diagnosis,early treatment and improve the prognosis in the thrombosis oc-currence in ovarian cancer.
