Effects of preoperative parecoxib on interleukin 6 and postoperative analgesia for mastectomy
- VernacularTitle:帕瑞昔布钠术前用药对乳腺切除术患者血清 IL-6及术后镇痛的影响
- Author:
Peilan TENG
;
Derong XU
;
Jie YANG
;
Fengtong LI
;
Chen JIANG
- Publication Type:Journal Article
- Keywords:
Parecoxib;
Breast cancer;
Pain;
Interleukin 6
- From:
The Journal of Clinical Anesthesiology
2014;(12):1221-1222
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of preoperative parecoxib on the levels of inter-leukin 6 (IL-6)and postoperative analgesia for breast surgery.Methods Sixty breast cancer patients undergoing mastectomy were randomly divided into two groups:parecoxib group (group P)and con-trol group (group C),n=30 in each group.All patients received sevoflurane and fentanyl anesthesia. Group P was injected parecoxib 40 mg at 10 minutes before induction of anesthesia,meanwhile group C was injected saline 5 ml.All patients received postoperative patient-controlled intravenous analgesia (PCIA)with fentanyl.VAS scores for pain were assessed at postoperative 2,4,8,12,24 hours. The serum levels of IL-6 were measured by ELISA at 10 minutes before induction,4 h,8 h,and 24 h after surgery.Results Group P had lower VAS scores than group C at 2-12 h after surgery (P <0.05).Compared with 10 minutes before induction,the levels of IL-6 increased significantly at post-operative 4,8,24 h in two groups (P<0.01),while group P had lower levels of IL-6 than group C (P <0.01).Conclusion Preoperative administration of parecoxib has a stronger analgesic effect in breast cancer patients after mastectomy,and decreases the levels of IL-6.
