Research of liver toxicity and associated risk factors caused by nonˉnucleoside reverse transcriptase inhibittor
10.3969/j.issn.1673-4130.2014.24.013
- VernacularTitle:非核苷类反转录酶抑制剂引起的肝毒性及相关风险因素研究
- Author:
Depeng ZHOU
;
Lingyun LIANG
;
Fang LI
;
Hua XU
;
Lina WU
- Publication Type:Journal Article
- Keywords:
acquired immune deficiency syndrome;
highly active antiretroviral therapy;
liver toxicity
- From:
International Journal of Laboratory Medicine
2014;(24):3329-3331
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the occurrence rate of liver toxicity and related risk factors after receiving highly active an-tiretroviral-therapy(HAART)by the non-nucleoside reverse transcriptase inhibittor.Methods To observe the changes of liver func-tion indexes before and after antiviral therapy in 102 patients receiving HAART,the incidence rates of the liver toxicity were com-pared between nevirapine(NVP)and efavirenz(EFV)and the risk factors of liver toxicity after treatment were analyzed.Results A-mong 102 patients,73 cases accepted the treatment of NVP,the incidence rate of hepatotoxicity was 35.6%,29 cases accepted the treatment of EFV,the incidence rate of hepatotoxicity was 13.8%,the hepatotoxicity incidence rate had statistically significant difference between the two treatment methods(χ2 =4.761,P =0.029).Co-infected by hepatitis C virus(HCV)and baseline ALT el-evation were the independent risk factors of hepatotoxicity occurrence(P <0.05).Conclusion The patients receiving the treatment of NVP are more likely to have hepatotoxicity than the patients receiving the treatment of EFV.Co-infected by HCV and baseline ALT elevation are the independent risk factors of hepatotoxicity occurrence.
