Association between chromosome variations,abnormalities and male reproductive hormones level with spermatogenesis
10.3969/j.issn.1673-4130.2014.24.021
- VernacularTitle:染色体变异、畸变与男性生殖激素水平和精子生成的关系
- Author:
Hao LIU
;
Chunhui GENG
;
Kai SHEN
;
Yongxiang HUANG
;
Liyan ZHANG
;
Aiqun CHEN
- Publication Type:Journal Article
- Keywords:
chromosome abnormality;
chromosome variation;
reproductive hormones;
oligospermia;
azoospermia
- From:
International Journal of Laboratory Medicine
2014;(24):3347-3349
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between chromosome variations,abnormalities and male reproductive hor-mones level with spermatogenesis.Methods The chromosome karyotype,serum reproductive hormone including FSH,LH,T,PRL and E2,and semen were detected in 147 patients with male infertility or recurrent sponotaneous abortion.The results were per-formed the comparative analysis.Results Serum FSH,LH level and the incidence rate of azoospermia in the chromosome abnormal-ity group were significantly higher than those in the chromosome variation group and the normal group(P <0.05,P <0.01),serum T level was significantly lower than that in the chromosome variation group and the normal group(P <0.05).Serum FSH and the incidence rate of oligospermia in the Y chromosome variation group were significantly higher than those in the autosomal variation group(P <0.05).The incidence rate of azoospermia had no statistically significant difference between the Y chromosome variation and the autosomal variation group(P >0.05).Serum FSH,LH level and the incidence rate of azoospermia in the sex chromosome abnormality group were obviously higher than those in the autosomal abnormality group(P <0.05),the serum T level was signifi-cantly lower than that in the autosomal abnormality group(P <0.05).Conclusion The chromosome variation and abnormality are closely related with the reproductive hormones disorder and spermatogenetic function disorder.The obvious increase of serum FSH, LH level and obvious decrease of T level caused by sex chromosome variation and abnormality is one of the pathogenesis of oligo-spermia and azoospermia.
