Correlation between histology and serological index changes in patients with HBeAgˉnegative chronic hepatitis B
10.3969/j.issn.1673-4130.2014.24.023
- VernacularTitle:HBeAg阴性慢性乙型肝炎患者肝组织学与血清学指标改变相关性研究
- Author:
Hongxia QIU
;
Zhongxing YUAN
;
Yaqin LIU
;
Naigang GUO
- Publication Type:Journal Article
- Keywords:
chronic hepatitis B;
hepatitus Be antigen;
histology;
serology
- From:
International Journal of Laboratory Medicine
2014;(24):3352-3354
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between histology and serological index changes in the patients with HBeAg-neg-ative chronic hepatitis B(CHB).Methods 135 cases of HBeAg-negative CHB underwent the liver biopsy,HBV-DNA copy and de-tection of serum alanine aminotransferase(ALT),total bilirubin(TBiL),aspartate aminotransferase(AST),albumin(ALB),pro-thrombin activity(PTA),hyaluronic acid(HA)and laminin(LN).The relationship between the histopathological findings and the se-rological examination results were analyzed.Results There were statistically significant differences between serum HBV-DNA copy levels and the liver tissue inflammation grades(χ2 =23.64,P <0.05);serum ALT,TBiL,AST,ALB,PTA and HA concentrations in the high grade of inflammation were higher than those in the low grade of inflammation,the difference was statistically significant (P <0.05);in which the concentrations of serum ALT,TBiL,AST and HA were positively correlated with the inflammation grades (P <0.05);while ALB and PTA and HA were negatively correlated with the inflammation grades(P <0.05).Conclusion The ser-um level of HBV-DNA copy,TbiL,ALT,AST,ALB and PTA concentrations are related with the inflammatory grade of liver tissue in the patients with HBeAg negative CHB,the serum HA level is related with the fibrosis level of liver tissue.These indicators could provide the reference value for judging the disease condition and prognosis of HBeAg negative CHB patients.
