Role of Epithelial-mesenchymal Transition in Occurrence and Development of Gastric Cancer
10.3969/j.issn.1008-7125.2014.12.015
- VernacularTitle:上皮-间质转化在胃癌发生、发展中的作用
- Author:
Jinfeng DAI
;
Xiaoteng WANG
;
Chaoying CHEN
;
Bin Lü
- Publication Type:Journal Article
- Keywords:
Stomach Neoplasms;
Epithelial-Mesenchymal Transition;
Inflammation;
Drug Resistance;
Immune Escape
- From:
Chinese Journal of Gastroenterology
2014;(12):760-762
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial-mesenchymal transition( EMT ) and mesenchymal-epithelial transition are involved in the process of development of tissues and organs in embryonic stage. Currently studies are focused on the relationship between EMT and tumor invasion and metastasis. This article reviewed the role of EMT in the occurrence and development of gastric cancer by analyzing the relationship between EMT and gastritis,gastric mucosal barrier,initiation of gastric carcinogenesis, metastasis and invasion,drug resistance and immune escape which may provide insights to the pathologic mechanism and approaches to prevent and treat gastric cancer.
