Correlation of MMP-2 and TIMP-2 with Mesangial Proliferative Glomerulo-nephritis and Its Research Progress in Traditional Chinese Medicine
- VernacularTitle:系膜增生性肾小球肾炎与MMP-2、TIMP-2的关系及中医药研究进展
- Author:
Yingjie HU
;
Xianzhi REN
- Publication Type:Journal Article
- Keywords:
mesangial proliferative glomerulonephritis;
MMP-2;
TIMP-2;
traditional Chinese medicine;
review
- From:
Journal of Zhejiang Chinese Medical University
2014;(11):1342-1345
- CountryChina
- Language:Chinese
-
Abstract:
Objective] To explore both the correlation of matrix metal oproteinase and the imbalance of its tissue inhibitors-MMP-2 and TIMP-2 with glomerulosclerosis and its research progress in traditional Chinese medicine. [Methods] We generalized the research progress in traditional Chinese medicine from such aspects as the biological properties of MMP-2 and TMIP-2 and their mechanisms, their relationship with mesangial proliferative glomerulonephritis and effects of traditional Chinese medicine on their expression by searching the relevant literatures. [Results] Expressions of MMP-2 and TIMP-2 vary in different pathological stages(hyperplasia and sclerosis stage here) of glomerulonephritis, and traditional Chinese herbs could adjust their expressions in different stages. Traditional Chinese herbs can inhibit the development of glomerulosclerosis. [Conclusion] Applying traditional Chinese medicine in the treatment of mesangialproliferative glomerulonephritis could provide the base for further development of TCM as wel as a new choice for treating mesangialproliferative glomerulonephritis.
