Clinical significance of combination detection of BG and CD4 T limphocytes in early diagnosis of pulmonary invasive fungal infection in patients with AIDS
10.3969/j.issn.1673-4130.2014.24.011
- VernacularTitle:BG、CD4T淋巴细胞联合检测在早期诊断艾滋病患者肺部侵袭性真菌感染的临床意义
- Author:
Yongen LIN
;
Lina LONG
;
Liping REN
;
Binyao LI
;
Dong CHEN
- Publication Type:Journal Article
- Keywords:
(1-3)-β-D-dextran;
CD4T lymphocyte;
invasive fungal infection
- From:
International Journal of Laboratory Medicine
2014;(24):3325-3326
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the content of(1-3)-β-D-dextran(BG)and CD4T lymphocytes in order to early diagnose invasive pulmonary fungal infection(IPFI)in AIDS patients.Methods According to the qualified lower respiratory tract fungal culture re-sults,153 patients with pulmonary infection symptoms and definitely diagnosed AIDS were divided into the positive IPFI group(63 cases)and the negative IPFI group(90 cases);then plasma BG and CD4T lymphocytes were simultaneously detected in the positive IPFI group,negative IPFI group and 50 healthy controls.The same index was performed the pairwise comparison in each group and the statistical analysis was conducted.Results The mean values of BG and CD4T lymphocytes in the positive IPFI group were (56.30±15.38)pg/mL and(56±41)/μL;which in the negative IPFI group were(21.32±14.26)pg/mL and(200±53)/μL;which in the healthy control group were(2.89±1.55)pg/mL and(480±89)/μL.The pairwise comparison of BG and CD4T lymphocytes showed the statistical differences among the three groups by the t-test(P <0.01).Conclusion The combined detection of BG and CD4 lymphocyte has the value in early diagnosis of IPFI)on AIDS apparent infection.
