Research on relationship between thrombus precursor protein with diabetic microangiopathy
10.3969/j.issn.1673-4130.2014.24.019
- VernacularTitle:血栓前体蛋白与糖尿病微血管病变关系的研究
- Author:
Xiuling ZHANG
- Publication Type:Journal Article
- Keywords:
thrombus precursor protein;
diabetes mellitus;
diabetic microangiopathy;
cerebral infarction;
thrombus
- From:
International Journal of Laboratory Medicine
2014;(24):3343-3344
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the serum thrombus precursor protein(TpP)level in the patients with diabetic microangiopathy and to investigate the relationship between the changes of TpP concentrations and the diabetic microangiopathy.Methods 136 ca-ses of diabetic microangiopathy in the endocrinology and neurology departments of our hospital from July to December 2013 were selected as the research subjects and 58 healthy individuals with physical examination were selected as the normal control group(NC group).The serum TpP,Fib,D-dimer concentrations and PT,APTT were measured.The SPSS14.0 software package was adopted to perform the statistical processing.Results (1).Serum TpP concentration in the diabetic microangiopathy group was significantly higher than that in the NC group with statistical difference(P <0.05).There was no statistical differences in Fib,D-dimer,PT and APTT between the two groups(P >0.05).(2).According to whether or not complicating cerebral infarction,the diabetic microan-giopathy group was divided into two subgroups.and diabetic not merged cerebral infarction group.Serum TpP concentrations in the complicating cerebral infarction subgroup was significantly higher than that in the non-complicating cerebral infarction subgroup with statistical difference(P <0.05 ).Conclusion The serum TpP concentration in the diabetic microangiopathy is significantly higher than that in the control group,which indicating that the patient is in a hypercoagulable status the risk of thrombosis.The TpP detection may contribute to early diagnosis and timely treatment of thrombotic diseases for these patients.
