Clinical significance of bcl-6, p53, c-myc aberrations in diffuse large B-cell lymphoma
10.3760/cma.j.issn.1009-9921.2013.11.006
- VernacularTitle:bcl-6、p53、c-myc基因异常在弥漫大B细胞淋巴瘤中的临床意义
- Author:
Lanlan HE
;
Feng YAN
;
Deliang LIU
;
Xiangshan CAO
;
Xiaobao XIE
;
Zhilin WANG
- Publication Type:Journal Article
- Keywords:
Lymphoma,large B-cell,diffuse;
bcl-6 gene;
c-myc gene;
p53 gene
- From:
Journal of Leukemia & Lymphoma
2013;22(11):661-664
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate aberrations of bcl-6,p53,c-myc genes in diffuse large B-cell lymphoma (DLBCL) and its clinical significance.Methods Interphase fluorescence in situ hybridization (I-FISH) was detected in 59 DLBCL patients in vivo tissue bcl-6,p53 protein,c-myc gene status.The patients were treated with CHOP or R-CHOP chemotheralpy,and the survival rates and treatment efficiency were compared.Results The p53 deletion was detected in 18 of the 59 cases (30.5 ％),bcl-6 rearrangement in 11 cases (18.6 ％),5 cases with c-myc rearrangement (8.5 ％).In the aspects of remission rate,p53 deletion positive group contained less advantage than negative ones (33.3 ％ vs 75.6 ％,x2 =9.560,P =0.002).The prognosis of bcl-6 gene rearrangement positive group different from negative group,but the difference was not statistically significant (OS,P =0.107; PFS,P =0.094),p53 deletion positive patients was in significantly worse prognosis than the negative group (OS,P =0.031; PFS,P =0.028),c-myc rearrangement positive group difference in gene rearrangement negative group,but the difference was not statistically significant (OS,P =0.163; PFS,P =0.167).In the CHOP group,prognosis of p53 deletion,c-myc rearrangement positive group were significantly worse than the negative group,the difference was statistically significant (P ＜ 0.05).In R-CHOP group,the prognostic significance of bcl-6 gene rearrangement positive group were worse (OS,P =0.003; PFS,P =0.007).Conclusion DLBCL patients with bcl-6,p53,c-myc genes aberrations are related with poor prognosis,and they can be used as prognostic factors for predicting DLBCL and guiding therapy.
