Research Advances on Triterpenoid Saponins Biosynthesis and Its Key Enzymes
10.11842/wst.2014.11.028
- VernacularTitle:三萜皂苷生物合成途径及关键酶的研究进展＊
- Author:
Xiaoshuang XU
;
Fusheng ZHANG
;
Xuemei QIN
- Publication Type:Journal Article
- Keywords:
Triterpenoid saponins;
key enzymes;
cytochrome P450 monooxygenase;
UDP-glycosyltransferase
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(11):2440-2448
- CountryChina
- Language:Chinese
-
Abstract:
As an important kind of plant secondary metabolites and widely distributed in the plant kingdom, triter-penoid saponins have a variety of biological activities. The constitution and content of triterpenoid saponin are deter-mined by some key enzymes and their expressing level in triterpenoid saponins biosynthesis pathway. So, it is very important to illuminate the molecular mechanism of triterpenoid saponins biosynthetic pathway. In recent years, illu-mination of the entire biosynthetic pathway especially the confirmation and cloning of the key enzymes, such as squa-lene synthase, squalene epoxidase, cytochrome P450 monooxygenase and UDP-glycosyltransferase, had become one of the hot spots by many scholars. In this paper, the entire biosynthetic pathway and some kinds of key enzymes in-volved in the synthesis of carbon skeleton, and its oxidation, and glycation were reviewed for further demonstrating the biosynthetic pathway of triterpenoid saponins and providing a theoretical basis for artificial biosynthesis.
