Effect and safety of oral paracetamol in premature infants with patent ductus arteriosus
10.3969/j.issn.1006-5725.2014.22.038
- VernacularTitle:口服对乙酰氨基酚治疗早产儿动脉导管未闭的效果及安全性
- Author:
Jie ZHAO
;
Chuanzhong YANG
;
Qianshen ZHANG
;
Chaohui LIAN
;
Guoqing DONG
- Publication Type:Journal Article
- Keywords:
Paracetamol;
Ibuprofen;
Premature infants;
PDA
- From:
The Journal of Practical Medicine
2014;(22):3653-3655
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect and safety of paracetamol in premature infants with patent ductus arteriosus(PDA). Method A protrospective comparsion study was performed onthe data of premature infants with PDA. Seventy-two premature infants with echocardiographically comfirmed PDA were randomized into the oral paracetamol group(n1=18) and the ibuprofen group(n2=54), and the rate of ductal closure, side effects and complications were compared between the two groups. Results The ductus was 66.7% (12 infants) in the paracetamol group, which was similar to 70.4% (38 cases) in the ibuprofen group, with no significant difference(χ2=0.087,P=0.768).Except for the incidence of hyperbilirubinemia in the paracetamol group was higher than that in the ibuprofen group (P<0.05), no statistical differences were found in the other index (P>0.05), including oliguria,NEC,renal impairment,the incidence of IVH3-4 and gastrointestinal bleeding. Conclusions The clinical effect of paracetamol in premature infants with PDA is similar to that of ibuprofen , withlower incidence of hyperbilirubinemia, and paracetamol is worthy of amplication in clinical practice.
