Effect of Tanshinone ⅡA on nerve conduction of oxaliplatin induced peripheral neuropathy in rats
10.3969/j.issn.1006-5725.2014.21.016
- VernacularTitle:丹参酮ⅡA对奥沙利铂诱发的大鼠外周神经病变神经传导的影响
- Author:
Weiting CHENG
;
Kai XU
;
Zuowei HU
;
Shan WANG
;
Ming XIA
- Publication Type:Journal Article
- Keywords:
TanshinoneⅡA;
Oxaliplatin;
Peripheral neuropathy;
Nerve conduction velocity
- From:
The Journal of Practical Medicine
2014;(21):3411-3414
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of TanshinoneⅡA on nerve conduction of oxaliplatin induced peripheral neuropathy in rats. Methods Fifty Wistar rats were randomly divided into normal control group, model group, treatment group, prevention group, prevention and treatment group. Except for those in model group, Wistar rats were injected i.p. with oxaliplatin (20 mg/kg). The electrophysiological instrument were employed to detect the sciatic nerve conduction velocity, latency, amplitude 6 h, 24 h, 72 h and 7 d after modeling. Results In the model group, velocity of sciatic nerve conduction slowed, and latency prolonged 24 h after modeling (P<0.05) which continued to slow and prolong until 7 d after modeling (P<0.05). After the application of Tanshinone ⅡA, nerve conduction velocity became faster and latency shorter significantly (P <0.05), especially in the prevention and treatment group, in which no significant difference was found when compared with those in the normal control group (P > 0.05). Conclusions During the chemotherapy with oxaliplatin , TanshinoneⅡA can increase the conduction velocity of sciatic nerve , shorten the disease duration and play a protective role for peripheral nerve.
