Analysis of ischemic subtypes and risk factors of recurrence of ischemic stroke patients using antiplatelet drugs
10.3969/j.issn.1006-5725.2014.21.017
- VernacularTitle:脑梗死患者抗血小板二级预防后再发脑梗死的类型及危险因素分析
- Author:
Xiaodan ZHANG
;
Yuanrong YAO
- Publication Type:Journal Article
- Keywords:
Ischemic stroke;
Coronary heart disease;
Smoking;
Diabetes mellitus;
Low density lipoprotein
- From:
The Journal of Practical Medicine
2014;(21):3415-3418
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore types and risk factors of recurrent ischemic stroke in ischemic stroke patients using antiplatelet drugs. Methods By retrospective study, 130 recurrent ischemic stroke patients using antiplatelet drugs (antiplatelet therapy group) and 101 recurrent ischemic stroke patients not taking antiplatelet drugs (non antiplatelet therapy group) were collected. Two groups of patients were divided according to the ischemic subtypes, and risk factors between different subtypes were analyzed. Results (1) Single factor analysis showed history of coronary heart disease and smoking are more frequent in antiplatelet therapy group with recurrent lacunar infarction (LI). History of coronary heart disease, diabetes, and high level of low density lipoprotein (LDL) are more frequent in antiplatelet therapy group suffer from recurrent atherosclerotic thrombosis (AT). (2)Logistic regression analysis showed the history of coronary heart disease , smoking are independent risk factors for recurrent LI in antiplatelet therapy group (P = 0.018, P = 0.027); history of coronary heart disease, diabetes, and high level of LDL are independent risk factors for recurrent AT in antiplatelet therapy group (P =0.003, P = 0.010, P = 0.002). Conclusions The history of coronary heart disease and smoking are independent risk factors for the recurrence of LI in patients with antiplatelet therapy. History of coronary heart disease , diabetes , and high level of LDL are independent risk factors for the recurrence of AT in patients with antiplatelet therapy. Combined coronary heart disease would increase both LI and AT recurrence.
