The interaction between ALOX5AP SG13S114A/T and COX-2 765G/C increases susceptibility to cerebral infarction
10.3969/j.issn.1006-5725.2014.21.019
- VernacularTitle:ALOX5AP基因SG13S114A／T和COX-2基因765G／C交互作用增加脑梗死的易感性
- Author:
Wanzhang CHI
;
Xingyang YI
;
Xuerong HUANG
;
Qiang ZHOU
;
Lifen CHI
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
5-lipoxygenase activating protein;
Single nucleotide Polymorphism;
Multifactor dimensionality reduction
- From:
The Journal of Practical Medicine
2014;(21):3422-3425
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the interrelations of ALOX5AP SG13S114A/T , COX-2 765G/C , COX-1-50C/T polymorphisms and cerebral infarction. Methods The ALOX5AP SG13S114A/T, COX-2 765G/C and COX-1 50C/T polymorphisms in 411 cases with cerebral infarction and 411 controls were measured by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism method. The generalized multifactor dimensionality reduction (GMDR) method was employed to detect gene-gene interactions. Results Single-gene analysis showed that there were no significant differences in the genotype and allele frequency distributions of ALOX5AP SG13S114A/T, COX-2 765G/C and COX-1 50C/T between two groups. However, in those cases carrying ALOX5AP SG13S114AA as well as COX-2 765CC , the risk of cerebral infarction increased significantly by 2.842 times. Conclusions The combinational analysis among genes used in this study may be helpful in the elucidation of genetic risk factors for common and complex diseases.
