Research progress on microRNA related to diffuse large B-cell lymphoma
10.3760/cma.j.issn.1009-9921.2012.12.020
- VernacularTitle:弥漫大B细胞淋巴瘤相关微小RNA的研究进展
- Author:
Lin LIU
- Publication Type:Journal Article
- Keywords:
Lymphoma,large B-cell,diffuse;
microRNA;
Molecular subtypes;
Diagnosis;
Treatment
- From:
Journal of Leukemia & Lymphoma
2012;21(12):763-766
- CountryChina
- Language:Chinese
-
Abstract:
microRNA (miRNA) is a class of endogenous small non-coding RNA (20-25 nt) which can regulate the expression of protein-coding genes post-transcriptionally and participate in a series of critical biological processes including cell proliferation,differentiation,metabolism,apoptosis,et al.Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype.DLBCL is defined as the malignant lymphoma which originates from the B cells,with aggressive clinical behaviors and significant clinical heterogeneity.In recent years,the researches on miRNA in DLBCL have shown that several kinds of miRNA directly involved in the occurrence and development of tumors and there is a correlation between the miRNA expression profiles and molecular subtypes of DLBCL.As a kind of new molecular target,miRNA has a broad prospect in the application both for diagnosis and biotherapy of DLBCL.
