Efficacy Evaluation ofDuhuo Jisheng Decoction in Treating Knee Osteoarthritis with Liver and Kidney Deficiency Syndrome by Ultrasound
10.3969/j.issn.1005-5304.2015.01.006
- VernacularTitle:基于关节超声评价独活寄生汤治疗肝肾亏虚型膝关节骨性关节炎临床疗效
- Author:
Xiaoli ZHOU
;
Qin SHAO
;
Ying ZHANG
;
Fang XIAO
- Publication Type:Journal Article
- Keywords:
Duhuo Jisheng Decoction;
knee osteoarthritis;
liver and kidney deficiency;
ultrasound
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;(1):18-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy ofDuhuo Jisheng Decoction in treating liver and kidney deficiency syndrome of knee osteoarthritis (KOA) by ultrasound.Methods A total of 120 cases of KOA patients with liver and kidney deficiency syndrome were randomly divided into two groups (each contains 60 cases). Control group took hydrochloric acid glucosamine capsules, while treatment group tookDuhuo Jisheng Decoction additionally for 8 weeks. ESR, CRP, WOMAC, joint swelling scores, and TCM syndrome scores of the two groups were determined, and the sonographic characteristics of knee-joint effusion in patellar fabricius, synovial membrane, cartilage and bone erosions were compared before and after treatment.Results There were significant differences in ESR, CRP, WOMAC, joint swelling scores, and TCM syndrome scores between before and after treatment in both groups (P<0.05,P<0.01). The knee-joint synovial membrane got thinner after therapy in osteoarthritis patients, and the effusion in knee-joint also decreased. The vessel flow signals in knee-joint synovial membrane of osteoarthritis decreased after drug therapy (P<0.05,P<0.01).ConclusionDuhuo Jisheng Decoction can improve clinical efficacy of KOA with liver and kidney deficiency syndrome. Ultrasound can clearly observe the changes of effusion in patellar fabricius, and synovial membrane, and can provide good imaging assessment for the drug therapy for KOA patients.
