Role of serum and urine NGAL in assessment of renal function in patients with primary hypertension
10.3969/j.issn.1000-484X.2014.12.019
- VernacularTitle:高血压肾病早期血尿NGAL水平的变化及临床意义
- Author:
Xinming ZHANG
;
Lingling LU
;
Feipei TU
;
Xiaofu PAN
- Publication Type:Journal Article
- Keywords:
NGAL;
Primary hypertension;
Kidney damage
- From:
Chinese Journal of Immunology
2014;(12):1672-1675
- CountryChina
- Language:Chinese
-
Abstract:
Objective:to investigate clinical significance of serum and urine NGAL (Neutrophil gelatinase-associated lipocalin) in the early kidney damage with primary hypertension.Methods:According to UAER ( urinary microalbumin excreting rate ) ,we divided 90 patients with primary hypertension into three groups (<30 mg/24 h,30-300 mg/24 h and >300 mg/24h),and selected 30 healthy people as the control group.Serum and urine NGAL and cystatin C ,serum creatinine,urea nitrogen,high sensitive C reactive protein , transferrin,and basis of blood pressure were detected and followed up one year.Results:Compared with healthy group ,GFR( glomerular filtration rate ) and serum NGAL were decreased significantly in medium and severe proteinuria groups , while urine NGAL was increased.Conclusion:Serum and urine NGAL have been a clear trend changes in kidney damage ,which could be used as a reliable indicator in monitoring renal function of patients with primary hypertension.
