Quantitative measurement of fatty liver by spectral imaging on gemstone CT:an experimental study on mice model
10.3969/j.issn.1002-1671.2014.12.036
- VernacularTitle:宝石 CT 能谱成像定量测定脂肪肝小鼠肝脏脂肪含量
- Author:
Tingting SHI
;
Jian HE
;
Jiong SHI
;
Shan JIANG
;
Bin XUE
;
Zhengyang ZHOU
;
Bin ZHU
- Publication Type:Journal Article
- Keywords:
fatty liver;
spectral CT imaging;
material analysis
- From:
Journal of Practical Radiology
2014;(12):2079-2083
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the feasibility of quantitative measurement of fat concentration by CT spectral imaging in a mice model of fatty liver.Methods Twenty-four mice with different degrees of fatty liver underwent CT spectral imaging.CT values of liver parenchyma under mixed X-ray energy and 65 keV,fat concentration based on various basic material pairs (fat/water,fat/io-dine,fat/calcium)and spectral curves were obtained.Liver specimens were obtained to measure the concentration of triglyceride , and HE staining was performed.Correlations between various CT indexes and triglyceride concentration were analyzed.Results Correlation between fat concentration (fat/water pair)and triglyceride (r =0.91 5 )was better than that between CT values on 65 keV and triglyceride (r=-0.858),as well as polychromatic CT values (r=-0.81 6).All the P values were<0.001.Correlations between fat concentrations based on fat/iodine or fat/calcium pairs and triglyceride were relatively low (r=-0.726,-0.660).CT indexes on 1.25 mm slice thickness performed better than those on 2.5 mm.With fatty liver degree increased,the shape of spectral curve changed gradually.Conclusion Liver fat concentration can be measured by CT spectral imaging noninvasively,accurately and quantitatively in a mice model of fatty liver.
