SRSF2 gene mutation and myeloid malignancies
10.3969/j.issn.1000-4718.2014.12.032
- VernacularTitle:SRSF2基因突变与髓系肿瘤
- Author:
Ningning MIAO
;
Fankai MENG
;
Wen ZENG
;
Shuang QIN
;
Dan LUO
;
Hanying SUN
- Publication Type:Journal Article
- Keywords:
Serine/arginine-rich splicing factor 2;
Myelodysplastic syndromes;
Chronic myelomonocytic leu-kemia;
Primary myelofibrosis
- From:
Chinese Journal of Pathophysiology
2014;(12):2289-2293
- CountryChina
- Language:Chinese
-
Abstract:
[ ABSTRACT] The splicing factors were characterized for their crucial roles in pre-mRNA splicing of eukaryons. SRSF2 is a member of the SR protein family which is one of the most common splicing factors, and it is believed to be a key element in pre-mRNA splicing, mRNA transcription, regulation of the DNA stability and cell proliferation.SRSF2 gene mutation is detected frequently in myeloid malignancies ( like MDS and CMML) and may be associated with the phenotype and prognosis of these malignancies.The paper makes a review for the latest research progression on SRSF2 gene mutation and its relationship with myeloid malignancies.
