Histopathologic Analysis of Malignant Lymphoma Involving the Skin and Its Relationship with the Epstein-Barr Virus.
- Author:
Yun Hee JIN
1
;
Seong Ho KIM
;
Chan Kum PARK
Author Information
1. Department of Pathology, College of Medicine, Hanyang University, Seoul 133-792, Korea.
- Publication Type:Original Article
- Keywords:
Malignant lymphoma;
Skin;
Epstein-Barr virus
- MeSH:
Classification;
Epstein-Barr Virus Infections;
Genome;
Herpesvirus 4, Human*;
In Situ Hybridization;
Lymphoma*;
Lymphoma, Follicular;
Lymphoma, Large-Cell, Anaplastic;
Lymphoma, T-Cell;
Lymphoma, T-Cell, Peripheral;
Lymphoproliferative Disorders;
Nasal Cavity;
Polymerase Chain Reaction;
RNA;
Skin*
- From:Korean Journal of Pathology
2000;34(1):20-28
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The author classified 38 cases of malignant lymphoma involving the skin primarily or secondarily by the new WHO classification with minor modifications and carried out RNA in situ hybridization and/or polymerase chain reaction (PCR) to investigate the role of Epstein-Barr virus (EBV). A case was follicular lymphoma of B cell origin and 37 cases were malignant lymphomas of T cell origin, including 15 cases of Mycosis fungoides/Sezary syndrome, five cases of subcutaneous panniculitis-like T cell lymphomas, a case of anaplastic large cell lymphoma, and four cases of primary cutaneous CD30 T cell lymphoproliferative disorders. There were eight cases of unspecified peripheral T cell lymphomas, in which four cases were composed of medium-sized cells, three cases of large cells, and a case of lymphoepithelioid cells. Four cases of nasal and nasal type NK/T cell lymphomas and three cases of unspecified peripheral T cell lymphomas showed EBV genome. The nasal and nasal type NK/T cell lymphomas, especially those involving the nasal cavity, showed close association with the EBV infection.
