Safety and effectiveness of high-intensity focused ultrasound ablation for liver tumor adjacent to rabbit abdominal aorta
10.3969/j.issn.1000-8179.20141176
- VernacularTitle:高强度聚焦超声消融兔腹主动脉旁肝肿瘤的安全性和有效性
- Author:
Lian SHUI
;
Min HE
;
Yingjiang LIU
;
Chunmei GONG
;
Lian ZHANG
- Publication Type:Journal Article
- Keywords:
high-intensity focused ultrasound;
rabbit;
abdominal aorta;
liver neoplasm;
magnetic resonance
- From:
Chinese Journal of Clinical Oncology
2014;(23):1517-1520
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the safety and efficacy of high-intensity focused ultrasound (HIFU) ablation for the VX2 liver tumor near the hepatic main blood vessels of rabbits by using dosimetry and magnetic resonance imaging (MRI) and by analyzing path-ological changes and survival. Methods:Rabbits with VX2 liver tumor adjacent to the abdominal aorta were divided into the HIFU (n=32) and control groups (n=20). MRI-guided HIFU was employed for the ablation of the liver tumor in the HIFU group. The ablation vol-ume and the energy efficiency factor (EEF) of the 32 ablated rabbits were further analyzed. MRI and pathology were used to compare the changes in the tumor before and after HIFU. The survival of the animals in the HIFU and control groups was also determined. Re-sults: Both pathology and imaging showed that the rabbit liver VX2 tumor adjacent to the abdominal aorta was completely ablated, with an EEF of (25.72±11.40) J/mm3. The survival rate was significantly higher in the HIFU group than in the control group (P<0.05). Conclusion: HIFU ablation is safe and effective in rabbit VX2 liver tumor near the abdominal aorta. This approach significantly in-creases survival.
