Expression of miR-17-92 cluster in osteosarcoma and its clinical significance
10.3969/j.issn.1000-8179.20141243
- VernacularTitle:miR-17-92基因簇在骨肉瘤中的表达及其临床意义
- Author:
Jinluan LIN
;
Fasheng WANG
;
Junjian YE
;
Zhaoyang WU
;
Xiang LI
;
Jianhua LIN
- Publication Type:Journal Article
- Keywords:
miR-17-92 cluster;
osteosarcoma;
prognosis
- From:
Chinese Journal of Clinical Oncology
2014;(23):1532-1535
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the expression of miR-17-92 cluster in osteosarcoma tissue samples and explore its associa-tion with clinical significance. Methods: Quantitative polymerase chain reactiom analysis was used to examine the expression of miR-17-92 cluster in osteosarcoma tissues. Normal bone tissues from 63 patients were matched, and the relationships between the ex-pression of miR-17-92 cluster and the clinicopathological features and prognosis of osteosarcoma were explored. Results:The relative expression of miR-17-92 cluster in osteosarcoma tissues was significantly higher than those in adjacent normal tissues (P<0.05). The high expression of miR-17-92 had a significant correlation with reduced survival (P=0.027). Conclusion:The expression of miR-17-92 cluster closely correlates with the occurrence and progress of osteosarcoma and may be used as an indicator for osteosarcoma prognosis.
