Research progress on the role of hedgehog signaling pathway in gastric cancer
10.3969/j.issn.1000-8179.20141392
- VernacularTitle:胃癌Hedgehog通路研究进展
- Author:
Bin KE
;
Ning LIU
;
Han LIANG
- Publication Type:Journal Article
- Keywords:
signal transduction;
gastric cancer;
hedgehog signaling pathway
- From:
Chinese Journal of Clinical Oncology
2014;(23):1540-1543
- CountryChina
- Language:Chinese
-
Abstract:
Hedgehog (Hh) signaling pathway is critical during embryonic development. Recent studies have shown that Hh sig-naling plays an important role in oncogenesis and development of many malignant tumors. In particular, activation of the Hh signaling pathway is implicated in the aggressiveness and progression of gastric cancer. This review provides an overview of the research prog-ress on the role of Hh pathway in gastric cancer. Investigation of this pathway may reveal a novel target for gastric cancer therapy.
