Effect of Danhong Injection on Levels of Serum S100 B Protein and Neuron_specific Enolase in Patients with Acute Cerebral Infarction
10.3870∕yydb.2014.12.014
- VernacularTitle:丹红注射液对急性脑梗死患者血清S100 B蛋白和神经元特异性烯醇化酶的影响
- Author:
Ming LI
;
Qiang LI
;
Mei ZHANG
;
Xiliu ZHANG
;
Qin HU
;
Yan PANG
- Publication Type:Journal Article
- Keywords:
Danhong injection;
Cerebral infarction,acute;
S100B Protein;
Neuron_sPecific enolase
- From:
Herald of Medicine
2014;(12):1596-1599
- CountryChina
- Language:Chinese
-
Abstract:
Objective To obserVe influence of danhong injection on leVels of serum S100B Protein and neuron_sPecific enolase ( NSE) in Patients with acute cerebral infarction ( ACI) ,and to exPlore its clinical effect. Methods Eighty cases of ACI were randomly diVided into treatment grouP and control grouP with 40 cases in each grouP. Both grouPs were giVen routine treatment according to the clinical guideline. Treatment grouP receiVed danhong injection once a day for 14 days. LeVels of serum S100B Protein and NSE were detected 1,3,5 and 10 days after ACI. The Patients in the two grouPs were eValuated by NIHSS 1 and 21 day(s) after ACI. Results ComPared with control grouP,leVels of serum S100B Protein and NSE were significantly lower in treatment grouP than in control grouP 3 and 5 days after ACI (all P<0. 01). NIHSS scores were significantly decreased 21 days after ACI in both grouPs,and NIHSS scores were lower in treatment grouP than in control grouP (P<0. 05). Peak concentration of S100B Protein in treatment grouP and control grouP was PositiVely correlated with NIHSS scores ( r=0. 761 and r=0. 792,resPectiVely,both P<0. 01). Conclusion Danhong injection can decrease serum S100B and NSE leVels,and imProVe the neurological function in ACI Patients.
