Transplantation of bone marrow mesenchymal stem cells in the treatment of bone nonunion following limb fractures:experimental results and conversion applications
10.3969/j.issn.2095-4344.2014.45.022
- VernacularTitle:骨髓间充质干细胞移植治疗四肢骨折骨不连：实验成果与转化应用
- Author:
Junli YANG
;
Xia HAN
;
Mingqi SUN
- Publication Type:Journal Article
- Keywords:
bone marrow;
mesenchymal stem cel transplantation;
fractures,bone
- From:
Chinese Journal of Tissue Engineering Research
2014;(45):7337-7341
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:As bone marrow mesenchymal stem cel s can be differentiated into osteoblasts under certain induction conditions, autologous bone marrow mesenchymal stem cel s can be implanted into the bone nonunion site of bone fracture. This new technology garners increasing attention of orthopedic clinicians.
OBJECTIVE:To summarize the clinical efficacy of transplantation of bone marrow mesenchymal stem cel s in the treatment of bone nonunion of limb fractures.
METHODS:A computer-based search of Foreign Medical Journal Ful-Text Service and CNKI databases was performed for articles related to bone marrow mesenchymal stem cel s for treatment of bone nonunion of limb fractures published from 1998 to 2014 using the keywords of“bone marrow stem cel s (BMSCs), stem cel transplantation (SCT), nonunions, tissue engineering”in English and Chinese, respectively. Literatures with repetitive content and lack of originality were excluded. A total of 36 literatures were obtained for further analysis. RESULTS AND CONCLUSION:Bone marrow mesenchymal stem cel s are transplanted into the end of bone nonunion, and then can be induced to differentiate into osteoblasts to repair bone nonunion and bone defects,
laying a theoretical basis for clinical application. Bone marrow mesenchymal stem cel s can repair bone defects, which provides an effective method and material to promote fracture healing. Transplantation of bone marrow mesenchymal stem cel s is safe and effective for treatment of bone nonunion of limb fracture.
