Development of Ebp1 in tumor proliferation and invasion
10.3969/j.issn.1000-8179.20141418
- VernacularTitle:Ebp1在肿瘤增殖和侵袭中的研究进展
- Author:
Yuan LIU
;
Fei ZHANG
;
Ruifang NIU
- Publication Type:Journal Article
- Keywords:
Ebp1;
tumor progression;
proliferation;
cell cycle;
invasion
- From:
Chinese Journal of Clinical Oncology
2014;(23):1536-1539
- CountryChina
- Language:Chinese
-
Abstract:
This work summarizes the research development and molecular mechanism of Ebp1, a member of the proliferation-associated 2G4 family, in tumor proliferation and invasion. This research serves as a basis and support for further research on the mechanism of tumor proliferation and invasion. The low expression of Ebp1 in various cancers promotes tumor proliferation and invasion. Ebp1 inhibits E2F1, cyclin D1, and cyclin E transcription by interacting with Rb, human histone deacetylase 2, and the transcriptional repressor Sin3A. This inhibition triggers cell cycle arrest and suppresses cell proliferation. Ebp1 also influences cancer invasion and migration. However, the underlying mechanisms remain unknown and require further exploration.
