Endothelial progenitor cells in fracture healing:problems about culture and transplantation
10.3969/j.issn.2095-4344.2014.45.025
- VernacularTitle:内皮祖细胞与骨折愈合：培养与移植中的问题
- Author:
Xinmin MENG
;
Xiaolei SUN
;
Jianxiong MA
;
Xinlong MA
- Publication Type:Journal Article
- Keywords:
endothelial cel s;
mesenchymal stem cel s;
vascular endothelial growth factors;
angiogenesis inducing agents
- From:
Chinese Journal of Tissue Engineering Research
2014;(45):7353-7357
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:With the development of biochemistry and cel biology, fracture has being study deeper, blood supply has been known to be an important factor influencing the fracture healing. Endothelial progenitor cel s with good ability of angiogenesis wil have a good clinical prospect in fracture healing.
OBJECTIVE:To review the recent research of endothelial progenitor cel s in fracture healing.
METHODS:A computer-based online search of CNKI, Wanfang, PubMed databases was performed to col ect articles published between 1980 and 2014 with the key words“endothelial progenitor cel , fracture, neovascularization, angiogenesis”in Chinese and English. A total of 48 articles addressing endothelial progenitor cel for angiogenesis in fracture healing were included in result analysis.
RESULTS AND CONCLUSION:Increasing evidence has shown that endothelial progenitor cel s have great ability of neovascularzition and angiogenesis. Endothelial progenitor cel s used in tissue engineering scaffolds can promote the survival rate of scaffolds in vivo, which is appropriate to a great part of delayed union and nonunion patients. However, the large-scale treatment with endothelial progenitor cel s stil has many problems, such as isolation, culture and amplification of endothelial progenitor cel s in vitro, the number of transplanted cel s and selection of scaffolds for transplanted cel s, which need further research.
