Research progress of induced pluripotent stem cells and its bottleneck
10.3969/j.issn.2095-4344.2014.45.026
- VernacularTitle:诱导多能干细胞的研究进展及其瓶颈
- Author:
Xun MA
;
Jie QIN
;
Yuming XU
- Publication Type:Journal Article
- Keywords:
induced pluripotent stem cel s;
nervous system diseases;
disease models
- From:
Chinese Journal of Tissue Engineering Research
2014;(45):7358-7363
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:With the development of the research, induced pluripotent stem cel s are applied to the build of disease model, drug screening, regenerative medicine, and many other research fields, and have made significant achievements, especial y in the study of nervous system diseases.
OBJECTIVE:To summarize the recent development of induced pluripotent stem cel s and to raise problems and prospects based on the latest research in this field.
METHODS:The first author searched the PubMed database for articles about the induced pluripotent stem cel s, including reviews, clinical research and basic research, published from January 2006 to September 2014. The keywords were“iPS, induced pluripotent stem cel”, and final y 60 articles were included in result analysis.
RESULTS AND CONCLUSION:Induced pluripotent stem cel research continues to make breakthrough from its discovery by Yamanaka’s team in 2006 to winning Nobel Prize in 2012. Induced pluripotent stem cel research has broad prospects in the disease model construction, drug screening and regenerative medicine. Currently, problems such as reprogramming methods, cel stability, and clinical transformation stil need to be solved, and further researches are necessary.
